解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.510
更新日期:1979-04-01 00:00:00
abstract::Mammalian spinal cord neurons were grown in dissociated cell culture and used to study the effects of the anticonvulsant barbiturates phenobarbital and mephobarbital, and the anesthetic barbiturates pentobarbital, secobarbital, and 1,3-dimethyl-butylethyl barbituric acid on amino acid responses and neuronal membrane p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.432
更新日期:1979-04-01 00:00:00
abstract::Relating the onset of clinical attacks as recorded on a videotape to surface and depth electrographic events improves our ability to define the local or diffuse origin of seizures. In two patients with complex partial seizures, all 14 attacks appeared 3 to 6 seconds after focal discharges began in the amygdala or hipp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.473
更新日期:1979-04-01 00:00:00
abstract::Parinaud syndrome, associated with a left thalamic hemorrhage, disappeared completely in a 57-year-old woman after ventriculoperitoneal shunt. The syndrome may be attributed to increased intracranial pressure owing to mass effect on the pretectal region and tectum, or to tightness in the incisura causing hydrocephalus...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.3.407
更新日期:1979-03-01 00:00:00
abstract::Two adult brothers became ill within 48 hours of each other, and both had severe myoglobinuria. One brother died of oliguric renal failure. The other did not have renal failure and survived. Acute influenza A infection was documented serologically and from throat washings in the surviving brother, and by isolation of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.3.340
更新日期:1979-03-01 00:00:00
abstract::Retraction of the lower eyelid is a useful sign of disease. It is an early manifestation of weakness of the facial muscles, occurring with myopathies, myasthenia, and upper and lower motor neuron facial paresis. Rarely, lower and upper lid retraction occur without proptosis in patients with Graves disease. Lower lid r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.3.386
更新日期:1979-03-01 00:00:00
abstract::We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.242
更新日期:1979-02-01 00:00:00
abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.170
更新日期:1979-02-01 00:00:00
abstract::Spasticity may result in part from segmental spinal disinhibition. We determined the content and specific activity of glycine (the putative neurotransmitter thought to mediate spinal postsynaptic inhibition) and serine (the probable precursor of glycine) in feline spastic spinal cord following the intra-aortic adminis...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.262
更新日期:1979-02-01 00:00:00
abstract::Creutzfeldt-Jakob disease was studied among Libyan-born Israelis, in whom the disease appears with unusual frequency. Interviews with relatives of deceased victims revealed statistically significant clustering within families. The results suggest either a common source of exposure or a genetic influence on susceptibil...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.225
更新日期:1979-02-01 00:00:00
abstract::A 52-year-old steelworker displayed a consistent defect in leftward voluntary gaze across the midline. Both fast (saccadic) and slow (pursuit) eye movements were affected. Neuro-ophthalmologic evaluation revealed no additional neurologic or ophthalmologic deficit. Pupilary miosis occurred during leftward gaze attempt,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.1.82
更新日期:1979-01-01 00:00:00
abstract::There have been few descriptions of spontaneous epidural hematoma of the spinal cord in children. Duration of symptoms in previous cases has varied from hours to days. We recently evaluated a 6-year-old girl with cord compression from an extradural clot, who complained of thoracic back pain for 3 months before becomin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.1.120
更新日期:1979-01-01 00:00:00
abstract::To study the incidence of abnormalities of the pyruvate (PDH) or ketoglutarate (KGDH) dehydrogenase complexes in patients with spinocerebellar degenerations, we measured the activities of PDH and KGDH in platelet-enriched preparations from the blood of 14 patients. Low PDH was found in 6 of the 14 patients; low KGDH w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.1.126
更新日期:1979-01-01 00:00:00
abstract::A physically and intellectually normally developed boy had a resection of a lumbar myelomeningocele shortly after birth and a shunt was inserted for hydrocephalus. He died at age 12 years after a traffic accident. Autopsy disclosed a hyperplasia of the cerebellar vermis. An abnormal median-sagittal triangular fiber tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.12.1302
更新日期:1978-12-01 00:00:00
abstract::Pathologic studies of women with fatal cerebrovascular disease who have received oral contraceptives are infrequently found in the literature. Three cases of this type are reported here. The pathologic findings included an intrinsic vascular lesion in the form of intimal hyperplasia with and without associated thrombo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.12.1216
更新日期:1978-12-01 00:00:00
abstract::Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.12.1241
更新日期:1978-12-01 00:00:00
abstract::The triad of normal-pressure hydrocephalus, parkinsonism, and primary empty sella appeared in a 70-year-old woman. There was dramatic resolution of the extrapyramidal signs and symptoms on treatment with levodopa-carbidopa and ventriculojugular shunt. The syndrome may be the result of several mechanisms, but an altera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.11.1191
更新日期:1978-11-01 00:00:00
abstract::Serum levels of creatine phosphokinase (CPK) and pyruvic kinase (PK) were determined in 42 controls, 57 patients with various neuromuscular disorders, and 23 female relatives of Duchenne dystrophy patients. CPK and PK enzyme activities were increased in comparable numbers of muscle disease patients and female carriers...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.10.1047
更新日期:1978-10-01 00:00:00
abstract::A double-blind crossover study with imipramine was conducted in 10 patients with absence and myoclonic-astatic seizures who had not responded to conventional medications. Imipramine produced a significant initial decrease in seizure frequency in 5 of the 10 patients, and in 2 patients the beneficial effect was maintai...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.28.9.953
更新日期:1978-09-01 00:00:00
abstract::Four prolonged episodes of partial complex status epilepticus were observed in a teenaged girl. During each there was an "ictal" phase, in which her mental state frequently fluctuated between mildly clouded consciousness and almost total unresponsiveness; once, she was also blind during this phase of impaired consciou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.9.863
更新日期:1978-09-01 00:00:00
abstract::Calcification in brainstem gliomas is an unusual histologic and and radiologic finding. To date, radiologic evidence of calcification in these tumors has not been reported. The two patients described here had evidence of calcification on either computerized tomography (CT) or plain skull films. Increasing availability...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.8.832
更新日期:1978-08-01 00:00:00
abstract::Between the years 1964 and 1973, 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis were evaluated and treated. They have now been followed for from 3 to 14 years (average 5.5 years). As of 1976, 82 of the 225 patients were dead, 21 from cerebral infarction, 52 from heart disease and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.8.746
更新日期:1978-08-01 00:00:00
abstract::We describe the clinical, pathologic, and ultrastructural findings in a case of juvenile onset neuronal ceroid-lipofuscinosis without visual symptoms or retinal abnormalities. The histochemical and ultrastructural characteristics of the neuronal lipopigment were similar to those in typical cases of neuronal ceroid-lip...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.7.710
更新日期:1978-07-01 00:00:00
abstract::Four adolescents had basilar migraine, infrequent cerebral seizures, and severe EEG abnormalities. The clinical course was benign, with normal personality, mentation, and neurologic examination. Almost continuous EEG abnormalities, consisting of rhythmic temporo-occipital sharp and slow wave discharges, or generalized...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.6.584
更新日期:1978-06-01 00:00:00
abstract::One hundred and eight multiple sclerosis (MS) patients and 108 matched controls were studied for antibody levels and cellular immune responses to several viruses. There were significant increases in the mean titers of complement fixation (CF) or hemagglutination inhibition (HI), and complement-mediated cytotoxicity (C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.6.613
更新日期:1978-06-01 00:00:00
abstract::A woman had a progressive neurologic syndrome beginning at age 3 and lasting for three decades. Clinical manifestations included severe mental deterioration, spastic paralysis, myoclonus, and tremors. A postmortem examination showed ubiquitous infiltration of neurons by lipofuscin and deposits of pigment in the globus...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.5.500
更新日期:1978-05-01 00:00:00
abstract::Mammalian spinal neurons grown in tissue culture were used to study the effects of the four convulsants-penicillin, pentylenetetrazol, picrotoxin, and bicuculline-on these neurons' responses to amino acids. Bath application of all four convulsants produced paroxysmal depolarizing events in the neurons; iontophoresis o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.4.325
更新日期:1978-04-01 00:00:00
abstract::While intracranial tuberculomas have become uncommon in industrial nations, 12 patients with signs and symptoms of an intracranial mass lesion were recently found to have tuberculomas. Clinical findings suggestive of tuberculosis were frequently subtle or absent. Five patients did not have extracranial tuberculosis. T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.3.256
更新日期:1978-03-01 00:00:00
abstract::Confusion, speech arrest, automatic behavior, and amnesia characterize the prolonged twilight states of both petit mal and psychomotor status. However, in psychomotor status two electroclinical phases were differentiated: (1) A continuous twilight state with partial responsiveness and reactive automatisms interrupted ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.3.239
更新日期:1978-03-01 00:00:00
abstract::Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; mot...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.28.2.158
更新日期:1978-02-01 00:00:00
abstract::A 20-year-old mentally retarded woman, who had a history of intractable epileptic seizures since early childhood, had prolonged episodes of confusion, decreased responsiveness and automatic behavior lasting as long as 2 days. These are believed to represent epileptic status of the complex partial (psychomotor) type be...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.2.189
更新日期:1978-02-01 00:00:00
abstract::The technique of intrathecal enhancement using metrizamide (Amipaque) combined with CT imaging enables both the morphologic and dynamic (serial) evaluation of the intracranial cerebrospinal fluid pathways. Three distinct metrizamide CT cisternographic patterns (delayed, intermediate, and normal) emerge in pediatric pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.1.71
更新日期:1978-01-01 00:00:00
abstract::In monkey extraocular muscles (EOM), a battery of histochemical reactions delineates three muscle fiber types, coarse, fine, and granular. Normal EOM are compared with EOM denervated by intracranial oculomotor nerve section. The experimentally denervated EOM fibers did not show the constellation of histologic response...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.1.55
更新日期:1978-01-01 00:00:00
abstract::Patients with myotonic dystrophy often develop respiratory failure caused by alveolar hypoventilation. Abnormalities in the ventilatory response to hypoxia and hypercapnia may explain this phenomenon. Accordingly, hypoxic and hypercapnic responses were measured in seven patients with myotonic dystrophy who had only mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.12.1125
更新日期:1977-12-01 00:00:00
abstract::A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.12.1157
更新日期:1977-12-01 00:00:00
abstract::Pathologic changes and distribution of lesions of the spinal cord were studied in 16 patients who suffered from "anoxic" episodes. The lesions were symmetrical and limited to the gray matter. The vulnerability of the spinal cord was most marked in the lumbosacral region, although almost every nucleus throughout the sp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.11.1049
更新日期:1977-11-01 00:00:00
abstract::Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month afte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.11.1053
更新日期:1977-11-01 00:00:00
abstract::Three family members intoxicated with methyl bromide presented with a variety of neuropsychiatric manifestations including coma, severe status epilepticus, hyporeflexia, and acute psychosis. The simulation of Reye syndrome in the child emphasizes the need for careful toxicologic screening of all children presenting wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.10.959
更新日期:1977-10-01 00:00:00
abstract::We have used computerized tomography (CT) to look for evidence of cerebral demyelination in children with progressive neurologic disorders. Fourteen patients with a clinical diagnosis of a demyelinating disorder were examined by CT, and five had CT findings suggesting cerebral demyelination. In two patients with a so-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.9.838
更新日期:1977-09-01 00:00:00
abstract::Two cases of giant-cell arteritis with cerebral arteritis are presented. The clinical situation and the suggestive but nonspecific angiographic features make the antemortem diagnosis possible. Greater awareness of this entity will facilitate its diagnosis and the institution of effective steroid therapy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.8.794
更新日期:1977-08-01 00:00:00